In the past six years, the two STEREO spacecraft have remotely observed hundreds of coronal mass ejections (CMEs), shedding light on their heliospheric evolution. Combined with global numerical simulations and multi-point in situ measurements, these observations can reveal intricate physical phenomena occurring during the propagation of CMEs between the Sun and the Earth. I will present recent simulations and observational results that give new insight on CME-CME interaction, but also raise new questions about CME heliospheric deflection and rotation as well as the nature of CMEs itself. I will also discuss some recent efforts in understanding the Sun-to-Earth evolution of complex series of eruptions as well as their geo-effectiveness and their effectiveness in accelerating particles, focusing on events from 2008 to 2011.